171 research outputs found
PSACNN: Pulse Sequence Adaptive Fast Whole Brain Segmentation
With the advent of convolutional neural networks~(CNN), supervised learning
methods are increasingly being used for whole brain segmentation. However, a
large, manually annotated training dataset of labeled brain images required to
train such supervised methods is frequently difficult to obtain or create. In
addition, existing training datasets are generally acquired with a homogeneous
magnetic resonance imaging~(MRI) acquisition protocol. CNNs trained on such
datasets are unable to generalize on test data with different acquisition
protocols. Modern neuroimaging studies and clinical trials are necessarily
multi-center initiatives with a wide variety of acquisition protocols. Despite
stringent protocol harmonization practices, it is very difficult to standardize
the gamut of MRI imaging parameters across scanners, field strengths, receive
coils etc., that affect image contrast. In this paper we propose a CNN-based
segmentation algorithm that, in addition to being highly accurate and fast, is
also resilient to variation in the input acquisition. Our approach relies on
building approximate forward models of pulse sequences that produce a typical
test image. For a given pulse sequence, we use its forward model to generate
plausible, synthetic training examples that appear as if they were acquired in
a scanner with that pulse sequence. Sampling over a wide variety of pulse
sequences results in a wide variety of augmented training examples that help
build an image contrast invariant model. Our method trains a single CNN that
can segment input MRI images with acquisition parameters as disparate as
-weighted and -weighted contrasts with only -weighted training
data. The segmentations generated are highly accurate with state-of-the-art
results~(overall Dice overlap), with a fast run time~( 45
seconds), and consistent across a wide range of acquisition protocols.Comment: Typo in author name corrected. Greves -> Grev
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Amygdala Perfusion Is Predicted by Its Functional Connectivity with the Ventromedial Prefrontal Cortex and Negative Affect
Background: Previous studies have shown that the activity of the amygdala is elevated in people experiencing clinical and subclinical levels of anxiety and depression (negative affect). It has been proposed that a reduction in inhibitory input to the amygdala from the prefrontal cortex and resultant over-activity of the amygdala underlies this association. Prior studies have found relationships between negative affect and 1) amygdala over-activity and 2) reduced amygdala-prefrontal connectivity. However, it is not known whether elevated amygdala activity is associated with decreased amygdala-prefrontal connectivity during negative affect states. Methods: Here we used resting-state arterial spin labeling (ASL) and blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) in combination to test this model, measuring the activity (regional cerebral blood flow, rCBF) and functional connectivity (correlated fluctuations in the BOLD signal) of one subregion of the amygdala with strong connections with the prefrontal cortex, the basolateral nucleus (BLA), and subsyndromal anxiety levels in 38 healthy subjects. Results: BLA rCBF was strongly correlated with anxiety levels. Moreover, both BLA rCBF and anxiety were inversely correlated with the strength of the functional coupling of the BLA with the caudal ventromedial prefrontal cortex. Lastly, BLA perfusion was found to be a mediator of the relationship between BLA-prefrontal connectivity and anxiety. Conclusions: These results show that both perfusion of the BLA and a measure of its functional coupling with the prefrontal cortex directly index anxiety levels in healthy subjects, and that low BLA-prefrontal connectivity may lead to increased BLA activity and resulting anxiety. Thus, these data provide key evidence for an often-cited circuitry model of negative affect, using a novel, multi-modal imaging approach
Learning the Effect of Registration Hyperparameters with HyperMorph
We introduce HyperMorph, a framework that facilitates efficient
hyperparameter tuning in learning-based deformable image registration.
Classical registration algorithms perform an iterative pair-wise optimization
to compute a deformation field that aligns two images. Recent learning-based
approaches leverage large image datasets to learn a function that rapidly
estimates a deformation for a given image pair. In both strategies, the
accuracy of the resulting spatial correspondences is strongly influenced by the
choice of certain hyperparameter values. However, an effective hyperparameter
search consumes substantial time and human effort as it often involves training
multiple models for different fixed hyperparameter values and may lead to
suboptimal registration. We propose an amortized hyperparameter learning
strategy to alleviate this burden by learning the impact of hyperparameters on
deformation fields. We design a meta network, or hypernetwork, that predicts
the parameters of a registration network for input hyperparameters, thereby
comprising a single model that generates the optimal deformation field
corresponding to given hyperparameter values. This strategy enables fast,
high-resolution hyperparameter search at test-time, reducing the inefficiency
of traditional approaches while increasing flexibility. We also demonstrate
additional benefits of HyperMorph, including enhanced robustness to model
initialization and the ability to rapidly identify optimal hyperparameter
values specific to a dataset, image contrast, task, or even anatomical region,
all without the need to retrain models. We make our code publicly available at
http://hypermorph.voxelmorph.net.Comment: Accepted for publication at the Journal of Machine Learning for
Biomedical Imaging (MELBA) at https://www.melba-journal.or
Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain
The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that the left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralized cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. The unique feature of the left AF is discussed in the context of the human capacity for language.National Institutes of Health (U.S.) (Grant R01NS069696)National Institutes of Health (U.S.) (Grant P41EB015896)National Institutes of Health (U.S.) (Grant S10ODRR031599)National Institutes of Health (U.S.) (Grant S10RR021110)National Science Foundation (U.S.) (Grant NFS-DMS-1042134)Uehara Memorial Foundation (Fellowship)Society of Nuclear Medicine and Molecular Imaging (Wagner-Torizuka Fellowship)United States. Dept. of Energy (Grant DE-SC0008430
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A Phenotype of Early Infancy Predicts Reactivity of the Amygdala in Male Adults
One of the central questions that has occupied those disciplines concerned with human development is the nature of continuities and discontinuities from birth to maturity. The amygdala plays a central role in the processing of novelty and emotion in the brain. While there is considerable variability among individuals in the reactivity of the amygdala to novel and emotional stimuli, the origin of these individual differences is not well understood. Four month old infants called high reactive (HR) demonstrate a distinctive pattern of vigorous motor activity and crying to specific unfamiliar visual, auditory, and olfactory stimuli in the laboratory. Low-reactive infants show the complementary pattern. Here we demonstrate that the HR infant phenotype predicts greater amygdalar reactivity to novel faces almost two decades later in adults. A prediction of individual differences in brain function at maturity can be made on the basis of a single behavioural assessment made in the laboratory at four months of age. This is the earliest known human behavioural phenotype that predicts individual differences in patterns of neural activity at maturity. These temperamental differences rooted in infancy may be relevant to understanding individual differences in vulnerability and resilience to clinical psychiatric disorder. Males who were HR infants showed particularly high-levels of reactivity to novel faces in the amygdala that distinguished them as adults from all other sex/temperament subgroups, suggesting that their amygdala is particularly prone to engagement by unfamiliar faces. These findings underline the importance of taking gender into account when studying the developmental neurobiology of human temperament and anxiety disorders. The genetic study of behavioral and biologic intermediate phenotypes (or âendophenotypesâ) indexing anxiety-proneness offers an important alternative to examining phenotypes based on clinically-defined disorder. Because the HR phenotype is characterized by specific patterns of reactivity to elemental visual, olfactory, and auditory stimuli, well before complex social behaviors such as shyness or fearful interaction with strangers can be observed, it may be closer to underlying neurobiological mechanisms than behavioral profiles observed later in life. This possibility, together with the fact that environmental factors have less time to impact the four-month phenotype, suggests that this temperamental profile may be a fruitful target for high-risk genetic studies.Psycholog
Statistical analysis of longitudinal neuroimage data with linear mixed effects models
Longitudinal neuroimaging (LNI) studies are rapidly becoming more prevalent and growing in size. Today, no standardized computational tools exist for the analysis of LNI data and widely used methods are sub-optimal for the types of data encountered in real-life studies. Linear Mixed Effects (LME) modeling, a mature approach well known in the statistics community, offers a powerful and versatile framework for analyzing real-life LNI data. This article presents the theory behind LME models, contrasts it with other popular approaches in the context of LNI, and is accompanied with an array of computational tools that will be made freely available through FreeSurfer -a popular Magnetic Resonance Image (MRI) analysis software package. Our core contribution is to provide a quantitative empirical evaluation of the performance of LME and competing alternatives popularly used in prior longitudinal structural MRI studies, namely repeated measures ANOVA and the analysis of annualized longitudinal change measures (e.g. atrophy rate). In our experiments, we analyzed MRI-derived longitudinal hippocampal volume and entorhinal cortex thickness measurements from a public dataset consisting of Alzheimer's patients, subjects with mild cognitive impairment and healthy controls. Our results suggest that the LME approach offers superior statistical power in detecting longitudinal group differences
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